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Article

Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos.

Mechanisms of development - 1 Mar 2004

Mitsunaga Kanae, Araki Kimi, Mizusaki Hirofumi, Morohashi Ken-Ichirou, Haruna Kyoko, Nakagata Naomi, Giguère Vincent, Yamamura Ken-Ichi, Abe Kuniya

Abstract excerpt

Estrogen related receptor beta (ERR-beta) is an orphan nuclear receptor specifically expressed in a subset of extra-embryonic ectoderm of post-implantation embryos. ERR-beta is essential for placental development since the ERR-beta null mutants die at 10.5dpc due to the placenta abnormality. Here, we show that the ERR-beta is specifically expressed in primordial germ cells (PGC), obviously another important cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15003627
DOI: 10.1016/j.mod.2004.01.006

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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