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Article

Do beta-tubulin mutations have a role in resistance to chemotherapy?

The Lancet. Oncology - 1 Mar 2004

Berrieman Helen K, Lind Michael J, Cawkwell Lynn

Abstract excerpt

beta-tubulin is the target of various antitubulin agents used in the treatment of cancer. After beta tubulin was shown to confer resistance to antitubulin agents in established cell lines, several studies have investigated the DNA sequence of this compound in clinical samples. However, these findings are highly controversial, since sequencing experiments showed that the original clinical observation of mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15003198
DOI: 10.1016/S1470-2045(04)01411-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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