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Article

Alterations of beta-tubulin isotypes in breast cancer cells resistant to docetaxel.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2005

Shalli Kawan, Brown Iain, Heys Steven D, Schofield Andrew C

Abstract excerpt

Docetaxel is one of the most active drugs used to treat breast cancer. The cellular target of docetaxel is the microtubule, specifically the beta-tubulin subunit, that comprises a series of isotypes and that can modulate function. This study has examined the role of alteration in beta-tubulin isotypes in vitro and has sequenced the beta-tubulin gene to determine if there were mutations, both of which may...

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Share to Antineoplastic Agents, Phytogenic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15946994
DOI: 10.1096/fj.04-3178fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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