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Article

Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 1999

Monzó M, Rosell R, Sánchez J J, Lee J S, O'Brate A, González-Larriba J L, Alberola V, Lorenzo J C, Núñez L, Ro J Y, Martín C

Abstract excerpt

PURPOSE: The mechanisms that cause chemoresistance in non-small-cell lung cancer (NSCLC) patients have yet to be clearly elucidated. Paclitaxel is a tubulin-disrupting agent that binds preferentially to beta-tubulin. Tubulins are guanosine triphosphate (GTP)-binding proteins. Beta-tubulin is a GTPase, whereas alpha-tubulin has no enzyme activity. We reasoned that polymerase chain reaction (PCR) and DNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10561216
DOI: 10.1200/JCO.1999.17.6.1786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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