Article
beta-Tubulin genes and the basis for benzimidazole sensitivity of the opportunistic fungus Cryptococcus neoformans.
Microbiology (Reading, England) - 1 Jun 1997
Cruz Maria Cristina, Edlind Thomas
Abstract excerpt
The basidiomycete Cryptococcus neoformans causes life-threatening infections in immunocompromised patients, and available chemotherapeutic agents are potentially toxic or have limited efficacy. In vitro, C. neoformans is very sensitive to selected benzimidazole compounds (e.g. albendazole), which...
Topics
- AIDS-Related Opportunistic Infections
- Amino Acid Sequence
- Base Sequence
- Benzimidazoles
- Cryptococcus neoformans
- Drug Resistance, Microbial
- Fungal Proteins
- Fungi
- Gene Amplification
- Gene Expression
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Tubulin