Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.

Biochemistry - 13 May 2003

Verdier-Pinard Pascal, Wang Fang, Martello Laura, Burd Berta, Orr George A, Horwitz Susan Band

Abstract excerpt

Six human alpha-tubulin and seven human beta-tubulin isotypes, each of which can undergo posttranslational modifications, have been detected by the reverse transcriptase-polymerase chain reaction. This repertoire of tubulin isotypes plays a role in development and in the building of specialized microtubule-based structures. In cell lines, the relationship between resistance to microtubule-interacting drugs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Burkitt Lymphoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Mass Spectrometry

Share to Ovarian Neoplasms

Share to Paclitaxel

Share to Protein Isoforms

Share to Tubulin

Source

Identifiers

PMID: 12731876
DOI: 10.1021/bi027293o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.PMID 12731876Read ↗

Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.Semantic proximity Read ↗

2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes.Semantic proximity Read ↗

The role of beta-tubulin isotypes in resistance to antimitotic drugs.Semantic proximity Read ↗

Alterations of beta-tubulin isotypes in breast cancer cells resistant to docetaxel.Semantic proximity Read ↗

The tubulin database: Linking mutations, modifications, ligands and local interactions.Semantic proximity Read ↗

Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes.Semantic proximity Read ↗

Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele.Semantic proximity Read ↗

Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.Semantic proximity Read ↗

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.Semantic proximity Read ↗

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceSemantic proximity Read ↗

Do beta-tubulin mutations have a role in resistance to chemotherapy?Semantic proximity Read ↗

Rationalization of paclitaxel insensitivity of yeast β-tubulin and human βIII-tubulin isotype using principal component analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.