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Article

Mutational analysis of the class I β‐tubulin gene in human breast cancer

25 Jul 2002

Abstract excerpt

Non-small cell lung cancers have a high incidence of somatic mutations of the beta-tubulin (class I) gene, suggesting involvement in the acquisition of resistance to taxanes, which exert their effects through binding to beta-tubulin. Since taxanes are often used in the treatment of breast cancer, we carried out a mutational analysis of the class I beta-tubulin (GenBank accession AF070600) gene in breast cancer....

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PMID: 12209587
DOI: 10.1002/ijc.10575

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