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Article

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.

Circulation research - 16 Apr 2004

Mar Rebecca, Pajukanta Päivi, Allayee Hooman, Groenendijk Martine, Dallinga-Thie Geesje, Krauss Ronald M, Sinsheimer Janet S, Cantor Rita M, de Bruin Tjerk W A, Lusis Aldons J

Abstract excerpt

The APOLIPOPROTEIN (APO)A1/C3/A4/A5 gene cluster on chromosome 11 has been hypothesized to be a modifier of plasma triglycerides in FCH. In the present study, we extended previous association analyses of the gene cluster to include APOA5, a newly discovered member of the cluster. Eight SNPs across the APOA1/C3/A4/A5 gene region were analyzed in 78 FCH probands and their normolipidemic spouses as well as in 27...

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Source

Identifiers

PMID: 15001527
DOI: 10.1161/01.RES.0000124922.61830.F0

Genes

APOA5
APOA1
APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.PMID 15001527Read ↗

Haplotype analyses of the APOA5 gene in patients with familial combined hyperlipidemia.Semantic proximity Read ↗

Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese.Semantic proximity Read ↗

Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.Semantic proximity Read ↗

Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11.Semantic proximity Read ↗

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese.Semantic proximity Read ↗

[A novel gene in APOA1/C3/A4/A5 cluster: apolipoprotein A5].Semantic proximity Read ↗

SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population.Semantic proximity Read ↗

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APOA1/C3/A4/A5 Gene Cluster at 11q23.3 and Lipid Metabolism Disorders: From Epigenetic Mechanisms to Clinical PracticesSemantic proximity Read ↗

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