Article
Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese.
Atherosclerosis - 1 Feb 2010
Liu Zhi-Kai, Hu Miao, Baum Larry, Thomas G Neil, Tomlinson Brian
Abstract excerpt
BACKGROUND: Familial combined hyperlipidaemia (FCH) is the most common genetic dyslipidaemia associated with coronary artery disease. Single nucleotide polymorphisms (SNPs) and haplotypes in the APOA1/C3/A4/A5 gene cluster are associated with FCH in Caucasians and with elevated triglycerides (TG) in various ethnic groups. We examined these associations with FCH in Hong Kong Chinese. METHODS: Fifty-six Chinese FCH...
Topics
- Adult
- Apolipoprotein A-I
- Apolipoprotein A-V
- Apolipoprotein C-III
- Apolipoproteins A
- Asian People
- China
- Female
- Haplotypes
- Hong Kong
- Humans
- Hyperlipidemias
- Linkage Disequilibrium
- Male
- Middle Aged
- Multigene Family
- Phenotype
- Polymorphism, Genetic