Article
Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2004
Eichenbaum-Voline Sophie, Olivier Michael, Jones Emma L, Naoumova Rossitza P, Jones Bethan, Gau Brian, Patel Hetal N, Seed Mary, Betteridge D John, Galton David J, Rubin Edward M, Scott James, Shoulders Carol C, Pennacchio Len A
Abstract excerpt
OBJECTIVE: Combined hyperlipidemia is a common disorder, characterized by a highly atherogenic lipoprotein profile and a substantially increased risk of coronary heart disease. The purpose of this study was to establish whether variations of apolipoprotein A5 (APOA5), a newly discovered gene of lipid metabolism located 30 kbp downstream of the APOA1/C3/A4 gene cluster, contributes to the transmission of familial...
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