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Article

The Contribution of GWAS Loci in Familial Dyslipidemias

26 May 2016

Abstract excerpt

Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease. The genetic architecture and contribution of rare Mendelian and common variants to FCH susceptibility is unknown. In 53 Finnish FCH families, we genotyped and imputed nine million variants in 715 family...

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PMID: 27227539
DOI: 10.1371/journal.pgen.1006078

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