Article
HIV fitness and resistance as covariates associated with the appearance of mutations under antiretroviral treatment.
Scandinavian journal of infectious diseases. Supplementum - 1 Jan 2003
Perno Carlo Federico, Cenci Alessandra, Piro Cristina, D'Arrigo Roberta, Marcon Luisa, Ceccherini-Silberstein Francesca, Ascoli Marchetti Franca, Caliò Raffaele, Antinori Andrea
Abstract excerpt
The ability of human immunodeficiency virus (HIV) strains to replicate in human target cells represents a major driving force of the progression of the disease. Despite antiretroviral treatment, HIV overcomes drug pressure by adding new (compensatory) mutations, appearing in a specific and sequential order, that modulate its replication capacity and favour viral escape. In the case of M184V (a mutation involving...
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