Article
The impact of the M184V substitution on drug resistance and viral fitness.
Expert review of anti-infective therapy - 1 Feb 2004
Wainberg Mark A
Abstract excerpt
Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance, limiting its use. Resistance mutations arise prior to therapy due to errors in HIV-1 replication, and are also spread by sexual and other modes of transmission. However, it is also generally believed that resistance is due to multiple drug mutations to any single or combination of antiretroviral agents selected during viral...
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