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Article

A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2004

Bogerd Hal P, Doehle Brian P, Wiegand Heather L, Cullen Bryan R

Abstract excerpt

The HIV type 1 (HIV-1) virion infectivity factor (Vif) protein blocks the action of the host defense factor APOBEC3G in human cells, thereby allowing release of infectious virions, but fails to inhibit similar APOBEC3G proteins present in some simian cells. Conversely, the Vif protein encoded by the African green monkey (agm) simian immunodeficiency virus (SIV) can block agm APOBEC3G function but fails to inhibit...

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Identifiers

PMID: 14999100
DOI: 10.1073/pnas.0307713101
PMCID: PMC374319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.PMID 14999100Read ↗

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