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Article

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

Genes & development - 1 Feb 2000

Kung A L, Rebel V I, Bronson R T, Ch'ng L E, Sieff C A, Livingston D M, Yao T P

Abstract excerpt

Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies. The latter are characterized, at least in some cases, by loss of heterozygosity (LOH) at the CBP locus. No such pathology was observed in wild-type or p300 heterozygous null mice of the same age and genetic...

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Identifiers

PMID: 10673499
PMCID: PMC316359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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