Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory activity of nm23-H1 on invasion and colonization of human prostate carcinoma cells is not mediated by its NDP kinase activity.

Cancer letters - 18 Oct 1999

Lee H Y, Lee H

Abstract excerpt

The human nm23-H1 gene product, a putative metastasis suppressor, was identified as nucleoside diphosphate kinase (NDPK) A isoform. To investigate the functional effect of nm23-H1's NDPK activity on its suppression of the components of metastatic phenotype, we transfected a human prostate carcinoma cell line, DU145, with the cDNA encoding nm23-H1 mutant protein lacking NDPK activity. The mutant nm23-H1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Monomeric GTP-Binding Proteins
Share to Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NM23 Nucleoside Diphosphate Kinases

Share to Nucleoside-Diphosphate Kinase

Share to Prostatic Neoplasms

Share to Tumor Cells, Cultured

Share to Tumor Stem Cell Assay

Source

Identifiers

PMID: 10530775
DOI: 10.1016/s0304-3835(99)00236-0

Genes

NDP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory activity of nm23-H1 on invasion and colonization of human prostate carcinoma cells is not mediated by its NDP kinase activity.PMID 10530775Read ↗

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to MetastasisSemantic proximity Read ↗

NDPKA is not just a metastasis suppressor - be aware of its metastasis-promoting role in neuroblastoma.Semantic proximity Read ↗

Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability.Semantic proximity Read ↗

Nucleoside diphosphate kinase A/nm23-H1 promotes metastasis of NB69-derived human neuroblastoma.Semantic proximity Read ↗

Nm23-H1 can induce cell cycle arrest and apoptosis in B cellsSemantic proximity Read ↗

Site-directed Mutagenesis of nm23-H1Semantic proximity Read ↗

NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.Semantic proximity Read ↗

Nm23-H1 Suppresses Tumor Cell Motility by Down-regulating the Lysophosphatidic Acid Receptor <i>EDG2</i>Semantic proximity Read ↗

NM23-H1 and NM23-H2 Repress Transcriptional Activities of Nuclease-hypersensitive Elements in the Platelet-derived Growth Factor-A PromoterSemantic proximity Read ↗

Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function.Semantic proximity Read ↗

Interplay between the antimetastatic nm23 and the retinoblastoma-related Rb2/p130 genes in promoting neuronal differentiation of PC12 cells.Semantic proximity Read ↗

The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.