Article
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nature communications - 16 Jul 2021
Garvie Colin W, Wu Xiaoyun, Papanastasiou Malvina, Lee Sooncheol, Fuller James, Schnitzler Gavin R, Horner Steven W, Baker Andrew, Zhang Terry, Mullahoo James P, Westlake Lindsay, Hoyt Stephanie H, Toetzl Marcus, Ranaghan Matthew J, de Waal Luc, McGaunn Joseph, Kaplan Bethany, Piccioni Federica, Yang Xiaoping, Lange Martin, Tersteegen Adrian, Raymond Donald, Lewis Timothy A, Carr Steven A, Cherniack Andrew D, Lemke Christopher T, Meyerson Matthew, Greulich Heidi
Abstract excerpt
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velcrins induce complex formation, and how the PDE3A-SLFN12 complex causes cancer cell death, are not fully understood. Here, we show that PDE3A and SLFN12 form a...
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