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Article

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.

The Journal of biological chemistry - 8 Mar 2013

Patwardhan Chaitanya A, Fauq Abdul, Peterson Laura B, Miller Charles, Blagg Brian S J, Chadli Ahmed

Abstract excerpt

Pharmacological inhibition of Hsp90 is an exciting option for cancer therapy. The clinical efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone p23 to Hsp90 and induced overexpression of anti-apoptotic proteins Hsp70 and Hsp27 are thought to contribute to this...

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Identifiers

PMID: 23355466
DOI: 10.1074/jbc.M112.427328
PMCID: PMC3591639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23355466-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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