Article
The stroma as a crucial target in rat mammary gland carcinogenesis.
Journal of cell science - 15 Mar 2004
Maffini Maricel V, Soto Ana M, Calabro Janine M, Ucci Angelo A, Sonnenschein Carlos
Abstract excerpt
A complex network of interactions between the stroma, the extracellular matrix and the epithelium drives mammary gland development and function. Two main assumptions in chemical carcinogenesis of the mammary gland have been that carcinogens induce neoplasia by causing mutations in the DNA of the epithelial cells and that the alterations of tissue architecture observed in neoplasms are a consequence of this...
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