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Article

Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma.

The American journal of pathology - 1 Nov 2005

Maffini Maricel V, Calabro Janine M, Soto Ana M, Sonnenschein Carlos

Abstract excerpt

There is mounting evidence that the stroma plays a crucial role in mammary gland carcinogenesis. Here, we report that mammary gland stroma from mature and multiparous rats prevents neoplastic development and encourages normal ductal growth of grafted epithelial cancer cells. Fifty thousand epithelial cancer cells were injected into the cleared fat pads of virgin hosts at 24, 52, 80, and 150 days of age and of...

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Identifiers

PMID: 16251424
DOI: 10.1016/S0002-9440(10)61227-8
PMCID: PMC1603788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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