Article
PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus.
Journal of bacteriology - 1 Apr 2008
Jakovljevic Vladimir, Leonardy Simone, Hoppert Michael, Søgaard-Andersen Lotte
Abstract excerpt
Type IV pili (T4P) are dynamic surface structures that undergo cycles of extension and retraction. T4P dynamics center on the PilB and PilT proteins, which are members of the secretion ATPase superfamily of proteins. Here, we show that PilB and PilT of the T4P system in Myxococcus xanthus have ATPase activity in vitro. Using a structure-guided approach, we systematically mutagenized PilB and PilT to resolve...
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