Article
A possible role of the cytochrome P450c17alpha gene (CYP17) polymorphism in the pathobiology of uterine leiomyomas from black South African women: a pilot study.
Acta obstetricia et gynecologica Scandinavica - 1 Mar 2004
Amant Frédéric, Dorfling Cecilia M, de Brabanter Jos, Vandewalle Joos, Vergote Ignace, Lindeque B G, van Rensburg Elizabeth J
Abstract excerpt
BACKGROUND: To investigate the role of the CYP17 gene promoter polymorphism in the pathobiology of uterine leiomyomas in African and Caucasian women. METHODS: During a 6-month period, 145 Caucasian and black South African women undergoing hysterectomy were included prospectively. Blood samples were obtained for DNA analysis. Factors modifying the risk for uterine leiomyoma growth such as age, parity, age at last...
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