CYP17 promoter polymorphism and breast cancer in Australian women under age forty years.

doi:10.1093/jnci/92.20.1674

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Article

CYP17 promoter polymorphism and breast cancer in Australian women under age forty years.

Journal of the National Cancer Institute - 18 Oct 2000

Spurdle A B, Hopper J L, Dite G S, Chen X, Cui J, McCredie M R, Giles G G, Southey M C, Venter D J, Easton D F, Chenevix-Trench G

Abstract excerpt

BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene. Because steroid hormone exposure is known to infl...

Topics

Adult
Age Factors
Age of Onset
Alleles
Australia
Breast Neoplasms
Case-Control Studies
DNA Primers
DNA, Neoplasm
Female
Genes, BRCA1
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Logistic Models

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 11036113
DOI: 10.1093/jnci/92.20.1674

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11036113-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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