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Article

CYP17 promoter polymorphism and breast cancer in Australian women under age forty years.

Journal of the National Cancer Institute - 18 Oct 2000

Spurdle A B, Hopper J L, Dite G S, Chen X, Cui J, McCredie M R, Giles G G, Southey M C, Venter D J, Easton D F, Chenevix-Trench G

Abstract excerpt

BACKGROUND: The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene. Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between...

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Source

Identifiers

PMID: 11036113
DOI: 10.1093/jnci/92.20.1674

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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