Article
Association of Cytochrome-17 (MspA1) Gene Polymorphism with Risk of Gall Bladder Stones and Cancer in North India.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Dwivedi Shipra, Agrawal Sarita, Singh Shraddha, Madeshiya Amit Kumar, Singh Devendra, Mahdi Abbas Ali, Chandra Abhjeet
Abstract excerpt
BACKGROUND: Cholelithiasis is associated in 54%-98% of patients with carcinoma of the gallbladder, and a high incidence among females suggests a role of female hormones in the etiology of the disease. Cytochrome P450C17α (CYP-17) is a key enzyme involved in estrogen metabolism and polymorphisms in CYP-17 are associated with altered serum levels of estrogens. Thus, we investigated whether the CYP-17 MspA1 gene...
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