Article
Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg.
DNA repair - 2 Mar 2005
Shiomi Naoko, Mori Masahiko, Kito Seiji, Harada Yoshi-Nobu, Tanaka Kiyoji, Shiomi Tadahiro
Abstract excerpt
In addition to xeroderma pigmentosum (XP), mutations in the human XPG gene cause an early onset of Cockayne syndrome (CS) in some patients (XP-G/CS) with characteristics, such as growth retardation and a short life span. In the previous studies, we generated four Xpg mutant mice with two different C-terminal truncations, null, or a base substitution mutation to identify the protein region that causes the onset of...
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