Article
A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997
Nouspikel T, Lalle P, Leadon S A, Cooper P K, Clarkson S G
Abstract excerpt
Xeroderma pigmentosum (XP) patients have defects in nucleotide excision repair (NER), the versatile repair pathway that removes UV-induced damage and other bulky DNA adducts. Patients with Cockayne syndrome (CS), another rare sun-sensitive disorder, are specifically defective in the preferential removal of damage from the transcribed strand of active genes, a process known as transcription-coupled repair. These...
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