Article
Muscarinic M(3) receptor-dependent regulation of airway smooth muscle contractile phenotype.
British journal of pharmacology - 1 Mar 2004
Gosens Reinoud, Bromhaar Mechteld M Grootte, Tonkes Annet, Schaafsma Dedmer, Zaagsma Johan, Nelemans S Adriaan, Meurs Herman
Abstract excerpt
1. Airway smooth muscle (ASM) cells are known to switch from a contractile to a proliferative and synthetic phenotype in culture in response to serum and growth factors. Phenotype switching in response to contractile agonists, however, is poorly characterised, despite the possible relationship between ASM phenotype and airway remodelling in asthma. 2. To investigate the effects of muscarinic receptor stimulation...
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