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Article

Focal caspase activation underlies the endplate myopathy in slow-channel syndrome.

Annals of neurology - 1 Mar 2004

Vohra Bhupinder P S, Groshong Jason S, Maselli Ricardo A, Verity M Anthony, Wollmann Robert L, Gomez Christopher M

Abstract excerpt

Slow-channel syndrome (SCS) is a progressive neuromuscular disorder caused by abnormal gating of mutant acetylcholine receptors (AChRs) in the neuromuscular junction (NMJ). The pathological hallmark is selective degeneration of the NMJ termed endplate myopathy. Endplate myopathy consists of a combination of ultrastructural abnormalities, including degenerating subsynaptic nuclei, mitochondria, and postsynaptic...

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Identifiers

PMID: 14991812
DOI: 10.1002/ana.10823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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