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Article

Caspase 3 activity is required for skeletal muscle differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002

Fernando Pasan, Kelly John F, Balazsi Kim, Slack Ruth S, Megeney Lynn A

Abstract excerpt

The cellular alterations associated with skeletal muscle differentiation share a high degree of similarity with key phenotypic changes usually ascribed to apoptosis. For example, actin fiber disassembly/reorganization is a conserved feature of both apoptosis and differentiating myoblasts and the conserved muscle contractile protein, myosin light chain kinase, is required for the apoptotic feature of membrane...

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Identifiers

PMID: 12177420
DOI: 10.1073/pnas.162172899
PMCID: PMC123204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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