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Caspase Pathways, Neuronal Apoptosis, and CNS Injury

1 Oct 2000

Abstract excerpt

Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation of other pro-apoptotic molecules. Based on their substrate specificities and DNA sequence...

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PMID: 11063050
DOI: 10.1089/neu.2000.17.811

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