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Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases

1 Jul 2001

Abstract excerpt

An analysis of programmed cell death of several populations of developing postmitotic neurons after genetic deletion of two key members of the caspase family of pro-apoptotic proteases, caspase-3 and caspase-9, indicates that normal neuronal loss occurs. Although the amount of cell death is not altered, the death process may be delayed, and the cells appear to use a nonapoptotic pathway of degeneration. The...

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PMID: 11425902
DOI: 10.1523/jneurosci.21-13-04752.2001

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