Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones.

Virology - 30 Mar 2006

Ariën Kevin K, Gali Youssef, El-Abdellati Abdelkarim, Heyndrickx Leo, Janssens Wouter, Vanham Guido

Abstract excerpt

CCR5-tropic viruses cause the vast majority of new HIV-1 infections while about half of the individuals infected with HIV-1 manifest a co-receptor switch (CCR5 (R5) to CXCR4 (X4)) prior to accelerated disease progression. The underlying biological mechanisms of X4 outgrowth in AIDS patients are still poorly understood. Although X4 viruses have been associated with increased "virulence" in vivo, in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to Genes, env

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to In Vitro Techniques

Share to Leukocytes, Mononuclear

Share to Peptide Fragments

Share to Receptors, CCR5

Share to Receptors, CXCR4

Source

Identifiers

PMID: 16386774
DOI: 10.1016/j.virol.2005.11.045

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replicative fitness of CCR5-using and CXCR4-using human immunodeficiency virus type 1 biological clones.PMID 16386774Read ↗

Phenotypic and genotypic comparisons of CCR5- and CXCR4-tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals.Semantic proximity Read ↗

Pairwise comparison of isogenic HIV-1 viruses: R5 phenotype replicates more efficiently than X4 phenotype in primary CD4+ T cells expressing physiological levels of CXCR4.Semantic proximity Read ↗

Evolution driven by a varying host environment selects for distinct HIV-1 entry phenotypes and other informative variantsSemantic proximity Read ↗

Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression.Semantic proximity Read ↗

Pathogenesis of HIV infectionSemantic proximity Read ↗

CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic.Semantic proximity Read ↗

Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing StrainsSemantic proximity Read ↗

Phenotypic properties of transmitted founder HIV-1.Semantic proximity Read ↗

Biological properties of HIV-1 subtype B' isolates from infected Chinese blood donors at different disease stages.Semantic proximity Read ↗

Replication capacity, biological phenotype, and drug resistance of HIV strains isolated from patients failing antiretroviral therapy.Semantic proximity Read ↗

Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching.Semantic proximity Read ↗

HIV-1 Tropism Determines Different Mutation Profiles in Proviral DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.