Article
Pairwise comparison of isogenic HIV-1 viruses: R5 phenotype replicates more efficiently than X4 phenotype in primary CD4+ T cells expressing physiological levels of CXCR4.
Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2010
Fiser Anne-Laure, Lin Yea-Lih, Portalès Pierre, Mettling Clément, Clot Jacques, Corbeau Pierre
Abstract excerpt
CCR5-using (R5) HIV-1 strains are present during the whole course of the infection in all subjects, whereas CXCR4-using (X4) HIV-1 strains appear only in the late stages of the infection in some subjects. In this study, we tested the hypothesis that this phenomenon might be the result of a replicative advantage of R5 over X4 strains. We compared the infectivity of an R5 and an X4 strain that differ only in their...
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