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Article

Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2004

Lammi Johanna, Huppunen Johanna, Aarnisalo Piia

Abstract excerpt

The orphan nuclear receptor Nurr1 is mainly expressed in the central nervous system but is also detected in certain peripheral tissues such as bone. To elucidate the role of Nurr1 in bone, we examined the ability of Nurr1 to regulate osteopontin (OPN) expression in osteoblastic cell lines. Transfection of Nurr1 in osteoblastic cells increased OPN mRNA expression. A dominant negative Nurr1 variant abolished the...

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PMID: 14988426
DOI: 10.1210/me.2003-0247

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PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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