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Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor

24 Jun 2020

Abstract excerpt

Bone mineralization is an orchestrated process by which mineral crystals are deposited by osteoblasts; however, the detailed mechanisms remain to be elucidated. The presence of P2X7 receptor (P2X7R) in immature and mature bone cells is well established, but contrasting evidence on its role in osteogenic differentiation and deposition of calcified bone matrix remains. To clarify these controversies in the present...

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PMID: 32583512
DOI: 10.1002/jcp.29891

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