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Article

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?

Diabetes, obesity & metabolism - 1 Jan 2006

Johansen A, Jensen D P, Bergholdt R, Mortensen H B, Pociot F, Nerup J, Hansen T, Pedersen O

Abstract excerpt

AIMS: Type 1 diabetes mellitus (T1DM) is a chronic disorder primarily triggered by environmental and immunological factors in genetically susceptible individuals. Despite the fact that there are indications of common aetiological features of T1DM and type 2 diabetes (T2DM), variation in genes inv...

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Source

Identifiers

PMID: 16367885
DOI: 10.1111/j.1463-1326.2005.00471.x

Genes

IRS1
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16367885-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?PMID 16367885Read ↗

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.Semantic proximity Read ↗

No association of multiple type 2 diabetes loci with type 1 diabetes.Semantic proximity Read ↗

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.Semantic proximity Read ↗

Association analysis of type 2 diabetes Loci in type 1 diabetes.Semantic proximity Read ↗

IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.Semantic proximity Read ↗

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.Semantic proximity Read ↗

The A98V single nucleotide polymorphism (SNP) in hepatic nuclear factor 1 alpha (HNF-1alpha) is associated with insulin sensitivity and beta-cell function.Semantic proximity Read ↗

[Two promising candidate genes in the ethiopathogenesis of DM2 - PPARgamma2 and KCNJ11].Semantic proximity Read ↗

A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.Semantic proximity Read ↗

The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.Semantic proximity Read ↗

Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case-control study in three ethnic groups from North-West India.Semantic proximity Read ↗

IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistanceSemantic proximity Read ↗

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