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Interplay between BMP2 and Notch signaling in endothelial-mesenchymal transition: implications for cardiac fibrosis

1 Sept 2023

Abstract excerpt

Background: The endothelial-to-mesenchymal transition (EndoMT) is a crucial process in cardiovascular development and disorders. Cardiac fibrosis, characterized by excessive collagen deposition, occurs in heart failure, leading to the organ remodeling. Embryonic signaling pathways such as bone morphogenetic protein 2 (BMP2) and Notch are involved in its regulation. However, the interplay between these pathways in...

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PMID: 37842185
DOI: 10.21037/sci-2023-019

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