Article
A broad range quorum sensing inhibitor working through sRNA inhibition.
Scientific reports - 29 Aug 2017
Jakobsen Tim H, Warming Anders N, Vejborg Rebecca M, Moscoso Joana A, Stegger Marc, Lorenzen Frederik, Rybtke Morten, Andersen Jens B, Petersen Rico, Andersen Paal Skytt, Nielsen Thomas E, Tolker-Nielsen Tim, Filloux Alain, Ingmer Hanne, Givskov Michael
Abstract excerpt
For the last decade, chemical control of bacterial virulence has received considerable attention. Ajoene, a sulfur-rich molecule from garlic has been shown to reduce expression of key quorum sensing regulated virulence factors in the opportunistic pathogen Pseudomonas aeruginosa. Here we show that the repressing effect of ajoene on quorum sensing occurs by inhibition of small regulatory RNAs (sRNA) in P....
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