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Article

A genome‐wide strategy for the identification of essential genes in <i>Staphylococcus aureus</i>

1 Mar 2002

Abstract excerpt

To address the need for new approaches to antibiotic drug development, we have identified a large number of essential genes for the bacterial pathogen, Staphylococcus aureus, using a rapid shotgun antisense RNA method. Staphylococcus aureus chromosomal DNA fragments were cloned into a xylose-inducible expression plasmid and transformed into S. aureus. Homology comparisons between 658 S. aureus genes identified in...

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PMID: 11952893
DOI: 10.1046/j.1365-2958.2002.02832.x

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