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Article

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition.

Psychopharmacology - 1 Aug 2004

Spooren Will, Mombereau Cedric, Maco Martine, Gill Rammy, Kemp John A, Ozmen Laurence, Nakanishi Shigetada, Higgins Guy A

Abstract excerpt

RATIONALE: Glutamate signalling through the N-methyl-D-aspartate (NMDA) receptor is of critical importance for normal central nervous system (CNS) function, as indicated by the marked behavioural disturbances produced by non-subtype selective NMDA antagonists such as dizocilpine (MK-801). OBJECTIVE: The present studies were designed to investigate the involvement of the two major NMDA receptor subunits in the...

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PMID: 14985927
DOI: 10.1007/s00213-004-1785-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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