Article
Relative frequencies of polymorphisms of variation in Block 2 repeats and 5' recombinant types of Plasmodium falciparum msp1 alleles.
Parasitology international - 1 Mar 2004
Sakihama Naoko, Matsuo Toshiaki, Mitamura Toshihide, Horii Toshihiro, Kimura Masatsugu, Kawabata Masato, Tanabe Kazuyuki
Abstract excerpt
The mechanisms producing the genetic polymorphism at Plasmodium falciparum merozoite surface antigen-1 locus (pfmsp1) include the insertion and deletion of the different type of dimorphic Block 2 9-nucleotide repeat units as well as the intragenic recombination. To study relative occurrence frequencies of these two distinct mechanisms, we have developed a sensitive PCR strategy to identify both 5' recombinant...
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