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Repeat Sequences in Block 2 of<i>Plasmodium falciparum</i>Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria

24 Mar 2003

Abstract excerpt

Human antibodies to the block 2 region of Plasmodium falciparum merozoite surface protein 1 (MSP1) are associated with a reduced prospective risk of clinical malaria. Block 2 is highly polymorphic, but all known alleles can be grouped into three major types. Two of these types (the K1-like and MAD20-like types) contain type-specific sequences (found in all alleles of a particular type) that flank polymorphic...

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Identifiers

PMID: 12654798
DOI: 10.1128/iai.71.4.1833-1842.2003

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