Article
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations.
Antimicrobial agents and chemotherapy - 1 Mar 2004
White Kirsten L, Chen James M, Margot Nicolas A, Wrin Terri, Petropoulos Christos J, Naeger Lisa K, Swaminathan S, Miller Michael D
Abstract excerpt
Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple thymidine analog (zidovudine [AZT], stavudine)-associated mutations and that confer high-level resistance to all currently approved chain-terminating nucleoside and nucleotide RT inhibitors (NRTIs). The two known mechanisms...
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