Article
Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance.
Antiviral therapy - 1 Dec 2003
Gallant Joel E, Gerondelis Peter Z, Wainberg Mark A, Shulman Nancy S, Haubrich Richard H, St Clair Marty, Lanier Ernest R, Hellmann Nicholas S, Richman Douglas D
Abstract excerpt
Although advances in highly active antiretroviral therapy (HAART) have made long-term suppression of HIV an achievable goal of therapy, a substantial proportion of first-line regimens will eventually fail. Successful longterm treatment requires consideration of downstream treatment options at the time of initiating or changing regimens. An understanding of the patterns and interactions of resistance mutations,...
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