Article
The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.
Antiviral therapy - 1 Jan 2006
White Kirsten L, Chen James M, Feng Joy Y, Margot Nicolas A, Ly John K, Ray Adrian S, Macarthur Holly L, McDermott Martin J, Swaminathan S, Miller Michael D
Abstract excerpt
The HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs) tenofovir (TFV), abacavir, didanosine and stavudine can select for K65R, whereas zidovudine (AZT) and stavudine can select for thymidine analogue mutations (TAMs) in HIV-1 reverse transcriptase (RT). HIV-1 with TAMs shows reduced susceptibility to all NRTIs, most notably AZT, whereas HIV-1 with K65R shows reduced susceptibility to all NRTIs except AZT....
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