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HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes.

Viruses - 25 Sept 2023

Cilento Maria E, Wen Xin, Reeve Aaron B, Ukah Obiaara B, Snyder Alexa A, Carrillo Ciro M, Smith Cole P, Edwards Kristin, Wahoski Claudia C, Kitzler Deborah R, Kodama Eiichi N, Mitsuya Hiroaki, Parniak Michael A, Tedbury Philip R, Sarafianos Stefan G

Abstract excerpt

Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4'-ethynyl-2-fluoro-2'-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furthermore, K65R and M184V increase sensitivity to ISL and TDF, respectively. Therefore, these two nucleoside analogs have opposing resistance profiles and could present a...

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Identifiers

PMID: 37896768
DOI: 10.3390/v15101990
PMCID: PMC10612037

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HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes.PMID 37896768Read ↗

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