Article
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy - 1 Jan 2007
Sluis-Cremer Nicolas, Sheen Chih-Wei, Zelina Shannon, Torres Pedro S Argoti, Parikh Urvi M, Mellors John W
Abstract excerpt
The K70E mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has become more prevalent in clinical samples, particularly in isolates derived from patients for whom triple-nucleoside regimens that include tenofovir (TNV), abacavir, and lamivudine (3TC) failed. To elucidate the molecular mechanism by which this mutation confers resistance to these nucleoside RT inhibitors (NRTI), we...
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