Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of human sperm DNA and background damage, analysed by in situ enzymatic treatment and digital image analysis

29 Jan 2004

Abstract excerpt

DNA breakage detection-fluorescence in situ hybridization (DBD-FISH) is a procedure to detect and quantify DNA breaks in situ, on a cell-by-cell basis. A comparison between sperm nuclei versus peripheral blood leukocytes using this method demonstrated that the nucleoids from mature human sperm are 12.7 times more sensitive to alkaline denaturation than those from human peripheral blood leukocytes. To investigate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14981148
DOI: 10.1093/molehr/gah029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of human sperm DNA and background damage, analysed by in situ enzymatic treatment and digital image analysisPMID 14981148Read ↗

DNA breakage detection-FISH (DBD-FISH) in human spermatozoa: technical variants evidence different structural featuresSemantic proximity Read ↗

The Sperm Chromatin Dispersion Test: A Simple Method for the Determination of Sperm DNA FragmentationSemantic proximity Read ↗

Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position reportSemantic proximity Read ↗

Sperm DNA damage causes genomic instability in early embryonic developmentSemantic proximity Read ↗

Mammalian Sperm DNA Susceptibility to In Situ Denaturation Associated with the Presence of DNA Strand Breaks as Measured by the Terminal Deoxynucleotidyl Transferase AssaySemantic proximity Read ↗

Mammalian sperm chromatin structure and assessment of DNA fragmentationSemantic proximity Read ↗

Distribution of DNA damage in the human sperm nucleus: implications of the architecture of the sperm headSemantic proximity Read ↗

Sperm chromatin structure: Insights from in vitro to in situ experimentsSemantic proximity Read ↗

Presence of DNA Strand Breaks and Increased Sensitivity of DNA in Situ to Denaturation in Abnormal Human Sperm Cells: Analogy to Apoptosis of Somatic CellsSemantic proximity Read ↗

Sperm DNA damage causes genomic instability in early embryonic developmentSemantic proximity Read ↗

Sperm nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo developmentSemantic proximity Read ↗

Species-Specific Differences in Sperm Chromatin Decondensation Between Eutherian Mammals Underlie Distinct Lysis RequirementsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.