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Article

Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.

Genetics - 1 Sept 2011

Ozdowski Emily F, Gayle Sophia, Bao Hong, Zhang Bing, Sherwood Nina T

Abstract excerpt

Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed extension or are transported. In both Drosophila and humans, loss of Spastin function results in...

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Identifiers

PMID: 21705760
DOI: 10.1534/genetics.111.130831
PMCID: PMC3176117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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