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The Biology of Acute Promyelocytic Leukemia and Its Impact on Diagnosis and Treatment

1 Jan 2006

Abstract excerpt

Several genetic and phenotypic characteristics of acute promyelocytic leukemia (APL) blasts provide relevant targets and the rationale for tailored treatment. These include the PML/RARalpha fusion and the transcription co-repressor complex recruited at the promoter of target genes by the hybrid protein, the intense and homogeneous expression of the CD33 antigen, absence of multidrug resistance-related phenotype,...

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PMID: 17124055
DOI: 10.1182/asheducation-2006.1.156

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